Citation

Vagnerova K, Koerner IP, Hurn PD. Anesth. Analg. 2008; 107(1): 201-214.

Affiliation

Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.

Copyright

(Copyright © 2008, International Anesthesia Research Society, Publisher Lippincott Williams and Wilkins)

DOI

10.1213/ane.0b013e31817326a5

PMID

18635489

PMCID

PMC2651745

Abstract

Anesthesiologists are frequently confronted with patients who are at risk for neurological complications due to perioperative stroke or prior traumatic brain injury. In this review, we address the growing and fascinating body of data that suggests gender and sex steroids influence the pathophysiology of injury and outcome for these patients. Cerebral ischemia, traumatic brain injury, and epilepsy are reviewed in the context of potential sex differences in mechanisms and outcomes of brain injury and the role of estrogen, progesterone, and androgens in shaping these processes. Lastly, implications for current and future perioperative and intensive care are identified.

Language: en