Citation

Farkhondeh T, Samarghandian S, Roshanravan B, Peivasteh-Roudsari L. Recent Pat. Food Nutr. Agric. 2019; ePub(ePub): ePub.

Affiliation

Devision of Food Safety and Hygiene, Department of Environmental Health, School of Public Health, Tehran University of Medical Sciences, Tehran. Iran.

Copyright

(Copyright © 2019, Bentham Science Publishers)

DOI

10.2174/2212798410666190617161523

PMID

31288732

Abstract

Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI.

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Language: en

Keywords

apoptosis; autophagy; curcumin; inflammation; oxidative stress; traumatic brain injury