Citation

Catharine VL, Helena V, Ellen D, Guy V, Karel D, Karen C. Neuroimage (Amst) 2019; 23: e101827.

Affiliation

Australian Catholic University, Mary McKillop Institute for Health Research Level 5, 215 Spring Street, Melbourne, VIC 3000, Australia. Electronic address: karen.caeyenberghs@acu.edu.au.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.nicl.2019.101827

PMID

31005776

Abstract

Sustaining a traumatic brain injury (TBI) during adolescence has a profound effect on brain development and can result in persistent executive functioning deficits in daily life. Cognitive recovery from pediatric-TBI relies on the potential of neuroplasticity, which can be fostered by restorative training-programs. However the structural mechanisms underlying cognitive recovery in the immature brain are poorly understood. This study investigated gray matter plasticity following 2 months of cognitive training in young patients with TBI. Sixteen adolescents in the chronic stage of moderate-severe-TBI (9 male, mean age = 15y8m ± 1y7m) were enrolled in a cognitive computerized training program for 8 weeks (5 times/week, 40 min/session). Pre-and post-intervention, and 6 months after completion of the training, participants underwent a comprehensive neurocognitive test-battery and anatomical Magnetic Resonance Imaging scans. We selected 9 cortical-subcortical Regions-Of-Interest associated with Executive Functioning (EF-ROIs) and 3 control regions from the Desikan-Killiany atlas. Baseline analyses showed significant decreased gray matter density in the superior frontal gyri p = 0.033, superior parietal gyri p = 0.015 and thalamus p = 0.006 in adolescents with TBI compared to age and gender matched controls. Linear mixed model analyses of longitudinal volumetric data of the EF-ROI revealed no strong evidence of training-related changes in the group with TBI. However, compared to the change over time in the control regions between post-intervention and 6 months follow-up, the change in the EF-ROIs showed a significant difference. Exploratory analyses revealed a negative correlation between the change on the Digit Symbol Substitution test and the change in volume of the putamen (r = -0.596, p = 0.015). This preliminary study contributes to the insights of training-related plasticity mechanisms after pediatric-TBI.

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Language: en

Keywords

Cognitive rehabilitation; Executive function; Gray matter; Linear mixed model analyses; Neural plasticity; Pediatric traumatic brain injury