Citation

Sukhodolskaya EM, Fehretdinova DI, Shibalev DV, Lazebny OE, Mabulla AZP, Butovskaya ML, Ryskov AP, Vasilyev VV. Ann. Hum. Genet. 2018; 82(6): 407-414.

Affiliation

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

Copyright

(Copyright © 2018, Cambridge University Press)

DOI

10.1111/ahg.12263

PMID

30009502

Abstract

The key regulator in the control of aggressive behavior is dopamine receptors. Association of variants in these genes with aggression has been shown in modern populations. However, these studies have not been conducted in traditional cultures. The aim of our study was to investigate population features in distributions of allele and genotype frequencies of DRD2 rs1800497, DRD4 120 bp Ins, and DRD4 exon III polymorphisms and their associations with aggressive behavior in the traditional African populations of Hadza and Datoga, which display a contrast in their culturally permitted aggression. Overall, 820 healthy unrelated Hadza and Datoga individuals were studied. Self-rated scores of aggression were collected using Buss and Perry's Aggression Questionnaire. Polymerase chain reaction-Restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotype of each individual. We show that the Hadza and the Datoga differed significantly in allele and genotype frequencies of all studied loci. Our association analysis detected that only ethnicity and sex of individuals significantly influenced their aggression rank, but we failed to identify any associations of DRD2 rs1800497, DRD4 120 bp Ins, or DRD4 exon III polymorphisms with aggression. Thus, our data have no strong evidence to support the involvement of polymorphisms of DRD2 and DRD4 in controlling aggressive behavior.

© 2018 John Wiley & Sons Ltd/University College London.

Language: en

Keywords

BPAQ; Datoga; Hadza; aggressive behavior; association study; dopamine receptors