Citation

Kim JA, Boyle E, Wu AC, Cole AJ, Staley KJ, Zafar S, Cash SS, Westover MB. Ann. Neurol. 2018; 83(4): 858-862.

Affiliation

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1002/ana.25211

PMID

29537656

Abstract

We hypothesize that epileptiform abnormalities (EA) in the electroencephalopgram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE₁). We analyzed PTE₁risk factors in two cohorts matched for TBI severity and age (n=50). EA independently predict risk for PTE₁(OR 3.16[0.99 11.68]); subdural hematoma is another independent risk factor (OR 4.13 [1.18 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest increased EA prevalence identifies patients at increased risk for PTE₁, and that EA acutely post-TBI can identify patients most likely to benefit from anti-epileptogenesis drug trials. This article is protected by copyright. All rights reserved.

© 2018 American Neurological Association.

Language: en

Keywords

EEG; epilepsy; traumatic brain injury