Citation

Estrada-Rojo F, Martínez-Tapia RJ, Estrada-Bernal F, Martinez-Vargas M, Perez-Arredondo A, Flores-Avalos L, Navarro L. Rev. Neurosci. 2018; 29(2): 139-149.

Affiliation

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Copyright

(Copyright © 2018, Freund Publishing)

DOI

10.1515/revneuro-2017-0028

PMID

28888093

Abstract

Traumatic brain injury (TBI) is a contemporary health problem and a leading cause of mortality and morbidity worldwide. Survivors of TBI frequently experience disabling long-term changes in cognition, sensorimotor function, and personality. A crucial step in understanding TBI and providing better treatment has been the use of models to mimic the event under controlled conditions. Here, we describe the known head injury models, which can be classified as whole animal (in vivo), in vitro, and mathematical models. We will also review the ways in which these models have advanced the knowledge of TBI.

Language: en

Keywords

in vitro models; in vivo models; ischemia; mathematical models; traumatic brain injury (TBI)