Citation

Savolainen H, Kurppa K, Tenhunen R, Kivistö H. Neurosci. Lett. 1980; 19(3): 319-323.

Copyright

(Copyright © 1980, Elsevier Publishing)

DOI

unavailable

PMID

6302602

Abstract

Male Wistar rats exposed to 1000 ppm carbon monoxide for 3 h showed a rapid removal of carbon monoxide from the blood, and a cerebral cytochrome oxidase activity within the control range immediately after the end of the exposure. The cytochrome oxidase activity decreased while carboxyhemoglobin concentration diminished during the reoxygenation period. The effect might have been caused through a loss of mitochondria by increased lipid peroxidation as cerebral glutathione concentration decreased and lysosomal acid proteinase activity increased in glial cell fractions. The present results seem to indicate that the cerebral cytochrome oxidase may not be specifically inhibited in non-lethal carbon monoxide poisoning despite its proven interactions in vitro.

Language: en