Citation

Chen TH, Kuo CH, Huang CT, Wang WL. Pediatr. Neonatol. 2013; ePub(ePub): ePub.

Affiliation

Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Emergency, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Pediatrics, True Generation Hospital, Kaohsiung, Taiwan. Electronic address: fordrwang@yahoo.com.tw.

Copyright

(Copyright © 2013, Elsevier Publishing)

DOI

10.1016/j.pedneo.2013.08.009

PMID

24332660

Abstract

Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic metabolites derived from the oxidation of methanol. However, clinical experience in pediatric methanol poisoning is limited, and the safety profiles of the antidotes have not been established in children, especially in Asian populations. This is the first case to describe the use of fomepizole in a child with methanol exposure in Taiwan.

Language: en