Citation

Grillner S. Neuron 2006; 52(5): 751-766.

Affiliation

Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden. sten.grillner@ki.se

Copyright

(Copyright © 2006, Cell Press)

DOI

10.1016/j.neuron.2006.11.008

PMID

17145498

Abstract

In 1900, Ramón y Cajal advanced the neuron doctrine, defining the neuron as the fundamental signaling unit of the nervous system. Over a century later, neurobiologists address the circuit doctrine: the logic of the core units of neuronal circuitry that control animal behavior. These are circuits that can be called into action for perceptual, conceptual, and motor tasks, and we now need to understand whether there are coherent and overriding principles that govern the design and function of these modules. The discovery of central motor programs has provided crucial insight into the logic of one prototypic set of neural circuits: those that generate motor patterns. In this review, I discuss the mode of operation of these pattern generator networks and consider the neural mechanisms through which they are selected and activated. In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks.

Language: en