Citation

Harenski CL, Thornton DM, Harenski KA, Decety J, Kiehl KA. Arch. Gen. Psychiatry 2012; 69(3): 283-292.

Affiliation

The Mind Research Network, 1101 Yale Blvd NE, Albuquerque, NM 87106. charenski@mrn.org.

Copyright

(Copyright © 2012, American Medical Association)

DOI

10.1001/archgenpsychiatry.2011.1566

PMID

22393220

Abstract

CONTEXT: Sexual sadism is a psychiatric disorder in which sexual pleasure is derived from inflicting pain, suffering, or humiliation on others. While the psychological and forensic aspects of sexual sadism have been well characterized, little is known about the neurocognitive circuitry associated with the disorder. Sexual sadists show increased peripheral sexual arousal when observing other individuals in pain. The neural mechanisms underlying this unusual response are not well understood. We predicted that sadists relative to nonsadists would show increased responses in brain regions associated with sexual arousal (amygdala, hypothalamus, and ventral striatum) and affective pain processing (anterior cingulate and anterior insula) during pain observation. OBJECTIVE: To study the neural correlates of pain observation in sadists and nonsadists. DESIGN: Case-control cross-sectional study. Sadists and nonsadists viewed 50 social scenes, 25 that depicted a person in pain (eg, one person stabbing another person's hand with scissors) and 25 thematically matched no-pain pictures (eg, one person stabbing a table with scissors, with another person's hand nearby). Pain severity ratings (range, 0 [none] to 4 [severe]) were acquired following each picture presentation. SETTING: Sand Ridge Secure Treatment Center, Mauston, Wisconsin. PARTICIPANTS: Fifteen violent sexual offenders, including 8 sadists and 7 nonsadists (defined using the Severe Sexual Sadism Scale) who were matched for age, IQ, and education. MAIN OUTCOME MEASURES: Hemodynamic response revealed by functional magnetic resonance imaging and pain severity ratings. RESULTS: Sadists relative to nonsadists showed greater amygdala activation when viewing pain pictures. They also rated pain pictures higher on pain severity than nonsadists. Sadists but not nonsadists showed a positive correlation between pain severity ratings and activity in the anterior insula. CONCLUSION: These results provide neurobehavioral evidence of unusually heightened sensitivity to the pain of others in sadists.

Language: en