Citation

Deegan C, O'Brien K. Paediatr. Anaesth. 2006; 16(2): 174-177.

Affiliation

Department of Anaesthesia and Intensive Care Medicine, Children's University Hospital, Temple Street, Dublin 1, Ireland.

Copyright

(Copyright © 2006, John Wiley and Sons)

DOI

10.1111/j.1460-9592.2005.01624.x

PMID

16430415

Abstract

We describe a case of a 2-year-old boy who ingested 35 mg.kg(-1) of amitriptyline. He developed central nervous system toxicity, as demonstrated by coma and seizures and cardiac toxicity (cardiac arrest) within 1 h of ingestion. The cardiac toxicity was refractory to standard therapy. His cardiac rhythm alternated between ventricular tachycardia and pulseless ventricular tachycardia/ventricular fibrillation for a period of 17 h. Following prolonged cardiopulmonary resuscitation and aggressive supportive management, the patient recovered both cardiovascularly and neurologically. An echocardiogram and MRI brain were subsequently performed and were normal. The patient was discharged 2 weeks later with normal cognitive, behavioral and motor function. We discuss the benefit of prolonged and effective cardiopulmonary resuscitation in the management of this potentially fatal poisoning.

Language: en