Citation

Widdop B, Medd RK, Braithwaite RA, Rees AJ, Goulding R. Arch. Toxicol. 1975; 34(1): 27-36.

Copyright

(Copyright © 1975, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

1242633

Abstract

Dogs were given large doses of barbiturates, glutethimide, ethanol, methaqualone, ethchlorvynol, meprobamate, chloral hydrate, paracetamol and aspirin. These were treated by haemoperfusion using a column packed with charcoal coated with an acrylic hydrogel. Clearances for most drugs were significantly higher than those reported for haemodialysis. Minimal clearances of common biochemical entities were observed and although leucocyte and platelet counts were diminished, no deleterious effects attributable to this were encountered. Careful histological examination of tissues derived from perfused dogs revealed no evidence of charcoal emboli.

Language: en