Citation

Hannon MJ, Sherlock M, Thompson CJ. Best Pract. Res. Clin. Endocrinol. Metab. 2011; 25(5): 783-798.

Affiliation

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Beaumont Road, Dublin 9, Ireland.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.beem.2011.06.001

PMID

21925078

Abstract

Traumatic brain injury and subarachnoid haemorrhage are important causes of morbidity and mortality in the developed world. There is a large body of evidence that demonstrates that both conditions may adversely affect pituitary function in both the acute and chronic phases of recovery. Diagnosis of hypopituitarism and accurate treatment of pituitary disorders offers the opportunity to improve mortality and outcome in both traumatic brain injury and subarachnoid haemorrhage. In this article, we will review the history and pathophysiology of pituitary function in the acute phase following traumatic brain injury and subarachnoid haemorrhage, and we will discuss in detail three key aspects of pituitary dysfunction which occur in the early course of TBI; acute cortisol deficiency, diabetes insipidus and SIAD.

Language: en