Citation

Okamoto M, Longenecker HE, Riker WF, Song SK. Science 1971; 172(984): 733-736.

Copyright

(Copyright © 1971, American Association for the Advancement of Science)

DOI

unavailable

PMID

4324667

Abstract

Black widow spider venom selectively poisons motor nerve endings. A progressive and irreversible failure of neuromuscular transmission occurs in the cat. Electron microscopy of the poisoned nerve-muscle junction shows a sequence of motor nerve ending damage that culminates in disruption of the prejunctional membrane and loss of all organelles, including synaptic vesicles. The postjunctional membrane was morphologically unaffected. After complete poisoning, the contractile response to exogenous acetylcholine was severely impaired, an indication that the prejunctional site is chiefly involved in the contractile response produced by exogenous acetylcholine and that the pre- and postjunctional effects of acetylcholine were separated.

Language: en