Citation

Andres-Barquin PJ, Hernandez MC, Israel MA. Neuroreport 1998; 9(18): 4075-4080.

Affiliation

Brain Tumor Research Center, Department of Neurological Surgery, School of Medicine, University of California San Francisco, 94143, USA.

Copyright

(Copyright © 1998, Lippincott Williams and Wilkins)

DOI

unavailable

PMID

9926850

Abstract

Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We examined the expression of Id genes in primary cultures of mouse forebrain astrocytes under experimental conditions in which astrogliosis was elicited by mechanical injury. Astrocyte cultures expressed the four known members of the Id gene family, Id1, Id2, Id3, and Id4. After injury, at a time when astrocytes developed the characteristic phenotypic changes of astrogliosis, Id4 expression decreased dramatically. Id1, Id2, and Id3 mRNA levels did not change. These results identify Id4 as a candidate marker of astroglial activation in culture and suggest that Id4 expression plays a role in the process of astrogliosis.

Language: en