Citation

Hatta K, Takahashi T, Nakamura H, Yamashiro H, Endo H, Kito K, Fujii S, Matsuzaki I, Masui K, Yonezawa Y. Neuropsychobiology 1999; 39(4): 196-199.

Affiliation

Department of Psychiatry, Tokyo Metropolitan Bokuto Hospital, Tokyo, Japan.

Copyright

(Copyright © 1999, Karger Publishers)

DOI

unavailable

PMID

10343184

Abstract

The aim of this study was to determine whether benzodiazepine tolerance might provide a predictive marker for persistent aggression in schizophrenia. Seventy-seven male schizophrenic patients newly admitted to our psychiatric intensive care unit due to violent behavior during a 4-month period were examined. As a result, a high dose of benzodiazepine required for sedation or a short duration until regaining consciousness after the initial sedation, was related to severer aggression on waking up after sedation. Despite the small number of subjects examined, a conservative claim can be made that the level of the effect of benzodiazepine required for sedation seems to predict persistent severe aggression in schizophrenia.

Language: en