Citation

Taitt CR, Malanoski AP, Lin B, Stenger DA, Ligler FS, Kusterbeck AW, Anderson GP, Harmon SE, Shriver-Lake LC, Pollack SK, Lennon DM, Lobo-Menendez F, Wang Z, Schnur JM. FEMS Immunol. Med. Microbiol. 2008; 54(3): 356-364.

Affiliation

Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA.

Copyright

(Copyright © 2008, Federation of European Microbiological Societies, Publisher John Wiley and Sons)

DOI

10.1111/j.1574-695X.2008.00486.x

PMID

19049648

Abstract

Timely identification of biothreat organisms from large numbers of clinical or environmental samples in potential outbreak or attack scenario is critical for effective diagnosis and treatment. This study aims to evaluate the potential of resequencing arrays for this purpose. Albeit suboptimal, this report demonstrated that respiratory pathogen microarray version 1 can identify Bacillus anthracis, Francisella tularensis, Yersinia pestis and distinguish them from benign 'near neighbor' species in a single assay. Additionally, the sequence information can discriminate strains and possibly the sources of the strains. With further development, it is possible to use resequencing microarrays for biothreat surveillance.

Language: en