Citation

Lee JW. Aust. N. Zeal. J. Psychiatry 1996; 30(4): 553-556.

Affiliation

Graylands Hospital, Mt Claremont, Australia.

Copyright

(Copyright © 1996, Royal Australian and New Zealand College of Psychiatrists, Publisher SAGE Publishing)

DOI

unavailable

PMID

8887709

Abstract

OBJECTIVE: A case of XXYY associated with schizophrenia is presented. CLINICAL PICTURE: A European male with tall stature, hypogonadism, and mild grade intellectual handicap with significantly lower verbal than performance Intelligence Quotient (IQ) exhibited features of chronic paranoid schizophrenia, along with impulsive aggression. TREATMENT AND OUTCOME: A trial of testosterone replacement exacerbated aggression. Psychotic symptoms persisted despite antipsychotic therapy. CONCLUSIONS: This is perhaps the first report of the XXYY syndrome associated with schizophrenia. The psychosis occurs more often in XXY and XXX than normal subjects, providing a clue to locating a gene predisposing to schizophrenia.

Language: en