Citation

Meier L, Hollinger A, Umbricht R, Tamborini P. Helv. Chir. Acta 1992; 59(2): 407-409.

Vernacular Title

Nekrose des terminalen Ileum nach Tablettenintoxikation. Fallbericht.

Affiliation

Chirurgische Abteilung, Kreisspital Männedorf.

Copyright

(Copyright © 1992, Schwabe)

DOI

unavailable

PMID

1428934

Abstract

In an attempt to commit suicide, a 32-year-old women swallowed a vast amount of psychiatric drugs, i.e. tranquilizers, amphetamines, hynotic and antidepressant agents. By intensive care, using high doses of catecholamines and appropriate antidota, satisfactory circulation and oxygenation could be maintained. 3 days after admission a peritonitis became apparent. A 50 cm long section of the distal ileum was found to be completely necrotic and had to be resected. However, circulation of the correspondent mesenterium was not disturbed at all. A drug-induced non-occlusive intestinal ischemia was postulated to be the pathophysiological mechanism of intestinal necrosis. Non-occlusive intestinal ischemia is rare; it has been reported in young adults intoxicated by cocaine or phenobarbital, in children with high overdosage of iron compounds, in elderly individuals suffering from low-output congestive heart disease and in patients treated with digitalis drugs, with or with or without overdosage.

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