Citation

Hiramoto K, Okada T, Ito M. Neuropsychobiology 1996; 33(4): 182-185.

Affiliation

Biochemical Research Institute, Nippon Menard Cosmetic Co., Ltd, Gifu, Japan.

Copyright

(Copyright © 1996, Karger Publishers)

DOI

unavailable

PMID

8840340

Abstract

Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched mice. Acetylcholine levels, acetylcholinesterase and choline acetyltransferase activities in the whole brains were decreased in both of 6- and 12-month irradiated mice. Only 1 of 6 mice irradiated for 12 months was histologically observed to have a drastic loss of bilateral hippocampal pyramidal cells in the CA1 field of Ammon's horn.

Language: en