Citation

Winn RE, McDonnell KP. Ann. Emerg. Med. 1993; 22(9): 1481-1484.

Affiliation

Department of Medicine, David Grant USAF Medical Center, Travis AFB, California.

Copyright

(Copyright © 1993, American College of Emergency Physicians, Publisher Elsevier Publishing)

DOI

unavailable

PMID

8363125

Abstract

A 19-year-old woman presented with status epilepticus and ventricular dysrhythmias less than one hour after ingesting 5,000 mg dimenhydrinate (Dramamine). Aggressive resuscitation including the use of physostigmine stabilized the cardiac rhythm; however, she suffered a severe neurologic deficit. Development of ischemic and infarcted bowel necessitated colonic resection. After surgery, her condition worsened, and after demonstration of minimal cerebral activity, supportive measures were withdrawn, and she died. Overdose with dimenhydrinate and diphenhydramine, both of which are over-the-counter drugs, can result in rapid central nervous system stimulation, including status epilepticus. Death can occur within two hours. To our knowledge, this is the first reported fatality resulting from ingestion of dimenhydrinate.

Language: en