Citation

López-Ibor JJ, Saiz-Ruiz J, Pérez de los Cobos JC. Neuropsychobiology 1985; 14(2): 67-74.

Copyright

(Copyright © 1985, Karger Publishers)

DOI

unavailable

PMID

2418384

Abstract

5-Hydroxyindoleacetic acid (5-HIAA) and cortisol in cerebrospinal fluid (CSF), response of the dexamethasone suppression test (DST) and the clinical response to treatment with 5-hydroxytryptophan (5-HTp) plus carbidopa were studied in a group of 21 depressed inpatients (major depression with melancholia) in order to correlate biological findings with psychopathologicalones. A positive correlation was found between strong suicidal thoughts, suicidal attempts and self-aggressivity and low concentration of 5-HIAA in CSF and a less significant but still positive correlation with abnormal DST response and with clinical response to the treatment.

Language: en