Citation

Dillon DG, Pizzagalli DA. Appl. Prev. Psychol. 2007; 12(3): 99-114.

Affiliation

Harvard University, Department of Psychology.

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/j.appsy.2007.09.004

PMID

19050749

PMCID

PMC2396584

Abstract

The neural bases of inhibitory function are reviewed, covering data from paradigms assessing inhibition of motor responses (antisaccade, go/nogo, stop-signal), cognitive sets (e.g., Wisconsin Card Sort Test), and emotion (fear extinction). The frontal cortex supports performance on these paradigms, but the specific neural circuitry varies: response inhibition depends upon fronto-basal ganglia networks, inhibition of cognitive sets is supported by orbitofrontal cortex, and retention of fear extinction reflects ventromedial prefrontal cortexamygdala interactions. Inhibition is thus neurobiologically heterogeneous, although right ventrolateral prefrontal cortex may support a general inhibitory process. Dysfunctions in these circuits may contribute to psychopathological conditions marked by inhibitory deficits.

Language: en