Citation

Serretti A, Calati R, Giegling I, Hartmann AM, Moller HJ, Rujescu D. J. Psychiatr. Res. 2009; 43(5): 519-525.

Affiliation

Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy.

Copyright

(Copyright © 2009, Elsevier Publishing)

DOI

10.1016/j.jpsychires.2008.06.005

PMID

18715570

Abstract

INTRODUCTION: Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE: In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS: The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. RESULTS: Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS: Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.

Language: en