Citation

Pumariega AJ, Nelson R, Rotenberg L. CNS Spectr. 2008; 13(6): 511-514.

Affiliation

Department of Psychiatry, The Reading Hospital and Medical Center, West Reading, PA 19612, USA.

Copyright

(Copyright © 2008, MBL Communications)

DOI

unavailable

PMID

18567975

Abstract

Varenicline is a promising agent with demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. We describe a case where mixed mood and psychotic disturbance developed in an individual with a history of depression and a family history of bipolar disorder. Based on this case, we hypothesize a possible mechanism of action for these adverse effects and preventive measures that could be undertaken in its effective use.

Language: en