Citation

Langsetmo L, Hanley DA, Kreiger N, Jamal SA, Prior J, Adachi JD, Davison KS, Kovacs C, Anastassiades T, Tenenhouse A, Goltzman D. Bone 2008; 43(4): 672-678.

Affiliation

CaMos National Coordinating Centre, McGill University, Montreal, Canada.

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.bone.2008.06.009

PMID

18640295

Abstract

BACKGROUND: Striking geographic variation in the incidence of osteoporotic fracture has been shown in national and international studies. The contributing risk factors for this variation are not fully understood. OBJECTIVE: To determine the geographic variation of bone mineral density (BMD) values, prevalent low-trauma fracture, prior falls, and vertebral deformity and to determine how this variation is related to the geographic variation of incident low-trauma fracture. METHODS: We studied incident fracture among 2484 men and 6093 women ages 50 and older from CaMos, a randomly-selected population-based longitudinal cohort recruited from within 50 kilometers of nine cities across Canada. Analyses included up to an eight-year follow-up. RESULTS: Estimates of fracture incidence are all age-standardized and given per 1000 person-years and CI denotes confidence interval. Among men, the lowest incidence of low-trauma fracture was 3.2 (95% CI: 1.1-7.5) in Quebec and the highest was 11.9 (95% CI: 7.1-18.6) in Calgary, compared with an overall incidence of 7.2 (95% CI: 5.8-8.7). Among women, the lowest incidence of low-trauma fracture was 11.5 (95% CI: 8.5-15.1) in Halifax and the highest was 18.5 (95% CI: 14.6-23.3) in Calgary, compared with an overall incidence of 15.3 (95% CI: 14.1-16.7). The regional variation in low-trauma fractures was similar to variation in hip fracture incidence among women (Pearson correlation, r=0.46 to 0.76) but not men (r=-0.06 to 0.05). We noted significant geographic variation in the prevalence of low BMD, as defined by BMD T-score

Language: en