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Journal Article

Citation

Currier D, Mann JJ. Psychiatr. Clin. North Am. 2008; 31(2): 247-269.

Affiliation

Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University, 1051 Riverside Drive, NYSPI Unit #42, New York, NY 10032, USA. dmc2111@columbia.edu

Copyright

(Copyright © 2008, Elsevier Publishing)

DOI

10.1016/j.psc.2008.01.005

PMID

18439448

PMCID

PMC2710608

Abstract

Suicidal behavior is partly heritable. Studies seeking the responsible candidate genes have examined genes involved in neurotransmitter systems shown to have altered function in suicide and attempted suicide. These neurotransmitter systems include the serotonergic, noradrenergic, and dopaminergic systems and the hypothalamic-pituitary-adrenal axis. With some exceptions, most notably the serotonin transporter gene promoter polymorphism (HTTLPR), replication of candidate gene association studies findings has been difficult. This article reviews current knowledge of specific gene effects and gene-environment interactions that influence risk for suicidal behavior. Effects of childhood stress on development and how it influences adult responses to current stress are shown to be relevant for mood disorders, aggressive/impulsive traits, and suicidal behavior.


Language: en

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