Citation

Carballo JJ, Akamnonu CP, Oquendo MA. Arch. Suicide Res. 2008; 12(2): 93-110.

Affiliation

New York State Psychiatric Institute and the College of Physicians and Surgeons of Columbia University, New York, NY.

Copyright

(Copyright © 2008, International Academy of Suicide Research, Publisher Informa - Taylor and Francis Group)

DOI

10.1080/13811110701857004

PMID

18340592

Abstract

Suicide is among the top ten leading causes of death in individuals of all ages. An explanatory model for suicidal behavior that links clinical and psychological risk factors or endophenotypes, to the underlying neurobiological abnormalities associated with suicidal behavior may enhance prediction, help identify treatment options and have heuristic value. Our explanatory model proposes that developmental factors that are biological (genetics) and psychological or clinical (early childhood adversity) may have causal relevance to the disturbances found in subjects with suicidal behavior. In this way, our model integrates findings from several perspectives in suicidology and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome.

Language: en