Citation

Freis ED. New Engl. J. Med. 1954; 251(25): 1006-1008.

Copyright

(Copyright © 1954, Massachusetts Medical Society)

DOI

10.1056/NEJM195412162512504

PMID

unavailable

Abstract

The introduction of Rauwolfia serpentina into this country by Wilkins and Judson1 and the purification of an active alkaloid, reserpine (Serpasil), has led to the widespread clinical use of the latter drug not only in hypertension2 , 3 but also in neuropsychiatric conditions.4 The purpose of this report is to describe the development of psychiatric complications in hypertensive patients treated with large doses of reserpine for long periods. Case Reports Case 1. Mrs. I.K., a 54-year-old widow, had mild hypertension for 1 year associated with headache and substernal pain. Since the death of her husband 2 years previously she had been more. . .

Keywords: Suicide