Citation

Olivia VR, Chira D, Chelaru VF, Diana CD, Livia LP, Buruiană AM, Mureşanu FD. J. Med. Life 2024; 17(3): 318-325.

Copyright

(Copyright © 2024, Carol Davila University Press)

DOI

10.25122/jml-2024-0187

PMID

39044922

PMCID

PMC11262599

Abstract

This secondary analysis of the CAPTAIN-RTMS trial data focused on the significance of quantitative electroencephalography (qEEG) indices as indicators of recovery in patients with traumatic brain injury (TBI). By focusing on the delta alpha ratio (DAR), delta theta/alpha beta ratio (DTABR), and theta beta ratio (TBR), this study explored the shifts in brainwave activity as a response to an integrative treatment regimen of repetitive transcranial magnetic stimulation (rTMS) combined with the neurotrophic agent Cerebrolysin.

FINDINGS revealed significant increases in DAR and DTABR, suggesting changes in neurophysiological dynamics after treatment. However, variations in TBR were inconclusive in providing clear electrophysiological insights. These results indicate that further research is necessary to describe and understand the underlying mechanisms of brain recovery and to develop refined treatment frameworks for patients with TBI.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; *Brain Injuries, Traumatic/therapy/physiopathology; *Electroencephalography/methods; *Transcranial Magnetic Stimulation/methods; Amino Acids; Cerebrolysin; DAR; DTABR; qEEG; rTMS; TBI; TBR