Citation

Schneider ALC, Pike JR, Elser H, Coresh J, Mosley TH, Diaz-Arrastia R, Gottesman RF. Alzheimers Dement. 2024; ePub(ePub): ePub.

Copyright

(Copyright © 2024, Alzheimer's Association, Publisher Elsevier Publishing)

DOI

10.1002/alz.14104

PMID

38970220

Abstract

INTRODUCTION: There is limited evidence regarding the rate of long-term cognitive decline after traumatic brain injury (TBI) among older adults.

METHODS: In this prospective cohort study, time-varying TBI was defined by self-report and International Classification of Disease diagnostic codes. Cognitive testing was performed at five visits over 30 years and scores were combined into a global cognition factor score. Adjusted linear mixed-effects models estimated the association of TBI with cognitive change.

RESULTS: A total of 11,701 Atherosclerosis Risk in Communities (ARIC) Study participants (mean baseline age 58 years, 58% female, 25% Black) without TBI at baseline were included. Over follow-up, 18% experienced TBI. The adjusted average decline in cognition per decade (standard deviation units) was more than twice as fast among individuals with ≥ 2 incident TBIs (

Keywords

traumatic brain injury; cohort study; cognitive decline