Citation

Chappell WP, Schur N, Vogel JA, Sammis GM, Melvin PR, Ball ND. Chem 2024; 10(6): 1644-1654.

Copyright

(Copyright © 2024)

DOI

10.1016/j.chempr.2024.04.008

PMID

38947532

PMCID

PMC11212144

Abstract

Organophosphorus(V) fluorides have a long and tumultuous history, with early applications as toxins and nerve agents reflecting their poisonous past. Behind these very real safety considerations, there is also growing potential in a wide range of fields, from chemical biology to drug development. The recent inclusion of organophosphorus(V) fluorides in click chemistry exemplifies the promise these compounds possess and brings these molecules to the brink of a resurgence. In this Perspective, we delve into the history of P(V)-F compounds, discuss the precautions needed to work with them safely, and explore recent advancements in their synthesis and application. We conclude by discussing how this field can continue on a path toward innovation.

Language: en

Keywords

Chemical biology; Click chemistry; Fluorine; Organophosphorus compounds; Phosphorus fluoride exchange chemistry; Synthetic methods