Citation

de Cuyper H. Acta Psychiatr. Belg. 1987; 87(3): 325-331.

Copyright

(Copyright © 1987, Acta Psychiatrica Belgica)

DOI

unavailable

PMID

unavailable

Abstract

Discusses studies on the relationship between disordered serotonin (5-HT) metabolism and manifestations of human (auto)aggression. The literature suggests a relationship between low cerebrospinal fluid (CSF) levels of 5-hydroxyindoleacetic acid (5-HIAA) in depressed patients and suicidal behavior. This diminished 5-HT metabolism has also been observed in patients with anxiety and personality disorders. It is suggested that there is also a relationship between disturbed aggression regulation and diminished central 5-HT metabolism.

METHODological shortcomings in biological suicide research, in particular problems with monoamine studies, are also addressed. (French & Dutch abstracts) (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Keywords

Aggression; Aggressive Behavior; Biochemistry; conference presentation; depressed patients; Depressive Disorder; Humans; Hydroxyindoleacetic Acid; Hydroxyindoleacetic Acid (5-); Major Depression; relationship between disordered 5-HT metabolism or CSF levels of 5-HIAA & disturbed aggression regulation; Serotonin; Serotonin Metabolites; Suicide; Suicide, Attempted