Citation

McKinzie CJ, Goralski JL, Noah TL, Retsch-Bogart GZ, Prieur MB. J. Cyst. Fibros. 2017; 16(4): 525-527.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.jcf.2017.05.008

PMID

28602538

Abstract

In both phase III studies of LUM/IVA, as well as an extension study, worsening of mental health was not reported as a common side effect. Here we describe five cases in adolescent female patients that suggest a worsening of anxiety or depression associated with its use. In these five patients, two experienced suicidal ideation and three made suicide attempts that resulted in psychiatric hospitalizations.

Language: en

Keywords

Humans; Child; Female; Adolescent; Anxiety; Depression; Suicidal Ideation; Suicide, Attempted; Withholding Treatment; Antidepressive Agents; Drug Combinations; Quinolones; CFTR modulator; Cognitive Behavioral Therapy; Cystic Fibrosis; Cystic fibrosis; Benzodioxoles; Aminophenols; Membrane Transport Modulators; Aminopyridines