Citation

Raivio TL. J. Bacteriol. 2018; 200(3): e00639-17.

Copyright

(Copyright © 2018, American Society for Microbiology)

DOI

10.1128/JB.00639-17

PMID

29109189

PMCID

PMC5763046

Abstract

Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology, Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.

Language: en

Keywords

Suicide; Escherichia coli; stress response; Escherichia coli Proteins; Heat-Shock Proteins; Proteolysis; bacterial envelope; DegP; Gram negative; Periplasmic Proteins; proteolysis; YjfN