Citation

Szmulewicz AG, Valerio MP, Lomastro J, Smith JM, Chiappe V, Martino DJ, Igoa A. J. Affect. Disord. 2018; 228: 97-100.

Copyright

(Copyright © 2018, Elsevier Publishing)

DOI

10.1016/j.jad.2017.12.015

PMID

29245093

Abstract

BACKGROUND: The aim of this study was to assess if an association between neurocognitive deficits and psychosocial functioning exists in first-episode BD patients.
METHODS: Twenty-five euthymic first-episode BD patients and thirty-seven healthy controls were recruited. History of suicide attempts, psychiatric comorbidities, pharmacological exposure, and previous depressive episodes were investigated. Performances on neurocognitive domains (verbal memory, attention, processing speed, and executive functions) as well as a measure of psychosocial functioning were used as outcomes.
RESULTS: First-episode BD patients showed medium-to-large size deficits on measures of attention, processing speed, and executive functions. A significant association between verbal memory and psychosocial functioning at the moment of BD diagnosis was detected (beta coefficient -3.9, IC 95% -6.7 to -1.2, p < 0.01).
CONCLUSIONS: A relationship between cognitive performance at the moment of BD diagnosis and psychosocial functioning was detected. Possible therapeutic implications of this finding are discussed.

Language: en

Keywords

Humans; Adult; Female; Male; Middle Aged; Young Adult; Cognition; Neuropsychological Tests; Attention; Executive Function; Bipolar Disorder; Memory; Reaction Time; Cyclothymic Disorder