Citation

Richardson T, Macaluso M. Expert Opin. Drug. Metab. Toxicol. 2017; 13(11): 1105-1113.

Copyright

(Copyright © 2017, Informa Healthcare)

DOI

10.1080/17425255.2017.1386653

PMID

28965429

Abstract

The goal of this paper is to provide a practical, clinically oriented review of lithium, a salt widely used to treat mania since the 1870s and formally approved as a mood stabilizer in 1970. Although lithium is still considered a first-line treatment for bipolar mania in most practice guidelines, its use may be overshadowed by newer psychotropic medications. Areas covered: This paper addresses the historical use of lithium, modern indications for its use, guidelines for prescribing and monitoring continued lithium use, drug-drug interactions, and pharmacodynamics/pharmacokinetic properties. The paper also reviews the unique properties of lithium and their potential clinical importance. Expert opinion: While the use of lithium does involve some unique risks to the patient, it may also has some unique advantages in certain patient populations. Two major findings that make lithium unique are its potential neuroprotective benefits and decreased risk of suicide in patients with mood disorders.

Language: en

Keywords

Humans; Practice Guidelines as Topic; Drug Interactions; bipolar disorder; Suicide Prevention; Lithium; bipolar depression; Bipolar Disorder; mania; Drug Monitoring; mood stabilizer; Antimanic Agents; Lithium Compounds; pharmacokinetics; pharmacodynamics; drug-drug interactions