Citation

Vallianou N, Giannopoulou M, Trigkidis K, Bei E, Margellou E, Apostolou T. Saudi J. Kidney Dis. Transpl. 2017; 28(4): 906-908.

Copyright

(Copyright © 2017, Saudi Center for Organ Transplantation, Publisher Medknow Publications)

DOI

unavailable

PMID

28748895

Abstract

Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression and presentation with coma is more common and could be lethal. Serious CNS toxicity often requires hemoperfusion and/or hemodialysis (HD). Herein, we present a case of a comatose patient, who was treated with a combination of hemoperfusion and HD in series. Our approach to treat the patient with a combination of hemoperfusion and HD was based on evidence from the literature supporting that the hemoperfusion and HD in series might provide the best clearance of carbamazepine.

Language: en

Keywords

Humans; Adult; Male; Drug Overdose; Treatment Outcome; Suicide, Attempted; Carbamazepine; Renal Dialysis; Combined Modality Therapy; Hemoperfusion; Anticonvulsants; Coma; Recovery of Function