Citation

Giuntoli L, Dalmastri V, Cilloni N, Orsi C, Stalteri L, Demelas V, Giuliani G, Gordini G, De Ponti F, La Manna G. Int. J. Artif. Organs 2019; 42(9): 516-520.

Copyright

(Copyright © 2019, Wichtig Editore)

DOI

10.1177/0391398819837686

PMID

31006356

Abstract

Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. This is the first published experience about the potential application of hemoadsorption therapies, as CytoSorb sorbent, in large overdoses of quetiapine and this approach might be feasible to rapidly remove the substance from blood, stabilizing the patient condition.

Language: en

Keywords

Humans; Adult; Female; Drug Overdose; Suicide, Attempted; Intensive Care Units; Antipsychotic Agents; hemoperfusion; Sorption Detoxification; artificial kidney; acute renal failure; Quetiapine Fumarate; Renal Replacement Therapy; Apheresis; apheresis and detoxification techniques; chronic renal failure; sorbents