Citation

Pardini M, Grafman J, Raymont V, Amore M, Serafini G, Koenigs M, Krueger F. CNS Spectr. 2020; 25(1): 24-31.

Copyright

(Copyright © 2020, MBL Communications)

DOI

10.1017/S1092852918001694

PMID

30968811

PMCID

PMC6786933

Abstract

OBJECTIVES: The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).
METHODS: Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.
RESULTS: Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.
CONCLUSIONS: The left rlPFC plays a crucial role in SI independently of depression and global functioning.

Language: en

Keywords

Humans; Male; Middle Aged; cognition; Tomography, X-Ray Computed; Suicidal Ideation; Cognition; traumatic brain injury; Suicidality; Veterans; Memory; frontal lobe; Prefrontal Cortex; Head Injuries, Penetrating; Brain Injuries, Traumatic