Citation

Nicotera AG, Hagerman RJ, Catania MV, Buono S, Di Nuovo S, Liprino EM, Stracuzzi E, Giusto S, Di Vita G, Musumeci SA. J. Autism Dev. Disord. 2019; 49(6): 2337-2347.

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s10803-019-03908-2

PMID

30726535

Abstract

To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features.

Language: en

Keywords

Humans; Child; Child, Preschool; Female; Male; Adolescent; Severity of Illness Index; Retrospective Studies; Young Adult; Pilot Projects; Cohort Studies; Biomarkers; Aggression; Electroencephalography; Phenotype; Autism spectrum disorder; Biomarker; Hyperactivity; Intellectual Disability; Autism Spectrum Disorder; Stereotyped Behavior; Epileptiform abnormalities