Citation

Nishitani N, Sasamori H, Ohmura Y, Yoshida T, Yoshioka M. J. Pharmacol. Sci. 2019; 141(3): 127-130.

Copyright

(Copyright © 2019, Japanese Pharmacological Society)

DOI

10.1016/j.jphs.2019.09.013

PMID

31690490

Abstract

High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs.

Language: en

Keywords

Male; Animals; Rats; Antipsychotics; Impulsive Behavior; Mental Disorders; Impulsive behavior; Antipsychotic Agents; Piperazines; Reaction Time; Behavior, Animal; Piperidines; Rats, Wistar; 1-PP