Citation

Doering S, Lichtenstein P, Gillberg C, Ntr, Middeldorp CM, Bartels M, Kuja-Halkola R, Lundström S. BMC Psychiatry 2019; 19(1): e363.

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/s12888-019-2349-3

PMID

31727035

PMCID

PMC6857289

Abstract

BACKGROUND: Anxiety disorders in adolescence have been associated with several psychiatric outcomes. We sought to describe the prospective relationship between various levels of adolescent anxiety and psychiatric diagnoses (anxiety-, bipolar/psychotic-, depressive-, and alcohol and drug misuse disorders) and suicidal ideation in early adulthood while adjusting for childhood attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD). Furthermore, we aimed to estimate the proportion attributable to the various anxiety levels for the outcomes.
METHODS: We used a nation-wide population-based Swedish twin study comprising 14,106 fifteen-year-old twins born in Sweden between 1994 and 2002 and a replication sample consisting of 9211 Dutch twins, born between 1985 and 1999. Adolescent anxiety was measured with parental and self-report. Psychiatric diagnoses and suicidal ideation were retrieved from the Swedish National Patient Register and via self-report.
RESULTS: Adolescent anxiety, of various levels, predicted, in the Swedish National Patient Register, anxiety disorders: hazard ratio (HR) = 4.92 (CI 3.33-7.28); depressive disorders: HR = 4.79 (3.23-7.08), and any psychiatric outcome: HR = 3.40 (2.58-4.48), when adjusting for ADHD, ASD, and DCD. The results were replicated in the Dutch data. The proportion of psychiatric outcome attributable to adolescent anxiety over time (age 15-21) was 29% for any psychiatric outcome, 43-40% for anxiety disorders, and 39-38% for depressive disorders.
CONCLUSION: Anxiety in adolescence constitutes an important risk factor in the development of psychiatric outcomes, revealing unique predictions for the different levels of anxiety, and beyond the risk conferred by childhood ADHD, ASD, and DCD. Developmental trajectories leading into psychiatric outcomes should further empirically investigated.

Language: en

Keywords

Humans; Risk Factors; Female; Male; Adolescent; Sweden; Young adulthood; Anxiety; Prospective Studies; Young Adult; Suicidal Ideation; Self Report; Longitudinal Studies; Adolescence; Suicidal ideation; Anxiety disorders; Predictive Value of Tests; Depressive Disorder; Depressive disorders; Attention Deficit Disorder with Hyperactivity; Twins; Neurodevelopmental disorders; Autism Spectrum Disorder; Diseases in Twins