Citation

Teske J, Weller JP, Albrecht UV, Fieguth A. J. Anal. Toxicol. 2011; 35(4): 248-253.

Copyright

(Copyright © 2011, Preston Publications)

DOI

10.1093/anatox/35.4.248

PMID

21513620

Abstract

A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of lethal suicidal brucine monointoxication, brucine concentrations of 1.51 μg/mL, 1.69 μg/mL, 9.94 μg/mL, 16.4 μg/g, 0.99 μg/g, 0.75 μg/g, and 1.95 mg/g were determined in femoral blood, urine, bile collected from the gallbladder, liver tissue, cerebellum, cerebrum, and stomach contents, respectively.

Language: en

Keywords

Humans; Female; Male; Middle Aged; Suicide; Poisoning; Fatal Outcome; Poisons; Diagnosis; Strychnine; Limit of Detection; Solid Phase Extraction