Citation

Riedel M, Mayr A, Seemüller F, Maier W, Klingberg S, Heuser I, Klosterkötter J, Gastpar M, Schmitt A, Sauer H, Schneider F, Gaebel W, Jäger M, Moller HJ, Schennach-Wolff R. World J. Biol. Psychiatry 2012; 13(1): 30-38.

Copyright

(Copyright © 2012, World Federation of the Societies of Biological Psychiatry, Publisher Informa - Taylor and Francis Group)

DOI

10.3109/15622975.2011.552633

PMID

21568628

Abstract

OBJECTIVE: To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol.
METHOD: A total of 274 patients were analysed within a double-blind randomized controlled trial and treated with risperidone or haloperidol. The patients were grouped according to their baseline HAMD-21 total score in a "depressed" (HAMD-21 ≥16) or "non-depressed" (HAMD-21 <16) patient subgroup. PANSS, HAMD-21, GAF, SOFAS and AIMS ratings were performed. Early response was defined as an initial 20% reduction of the PANSS total score from admission to week 2, response as an at least 50% reduction of the PANSS total score from admission to discharge and remission according to the consensus criteria.
RESULTS: A total of 124 patients were classified as depressive at baseline with 22 patients still being depressive at discharge. The depressed and non-depressed patients did not significantly differ regarding the treatment with risperidone and haloperidol (P = 0.2270). The depressive patients suffered from significantly more suicidal tendencies (P = 0.0165), had significantly less insight into their illness (P = 0.0152) and featured significantly worse functioning (P = 0.0066). Patients with depressive symptoms achieved remission significantly less often than non-depressed patients.
CONCLUSION: The importance of a specific and adequate treatment of depressive symptoms is highlighted.

Language: en

Keywords

Humans; Adult; Aged; Female; Male; Middle Aged; Adolescent; Depression; Young Adult; Psychiatric Status Rating Scales; Treatment Outcome; Suicidal Ideation; Double-Blind Method; Schizophrenia; Follow-Up Studies; Inpatients; Haloperidol; Hospitals, Psychiatric; Schizophrenic Psychology; Risperidone; Antipsychotic Agents; Remission Induction