Citation

Alluin A, Jezequel J, Gauthier N, Desmaretz JL, Canevet C. Ann. Fr. Anesth. Reanim. 2011; 30(10): 752-754.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.annfar.2011.05.019

PMID

21782376

Abstract

We present the case of a 24-year-old-female patient, who made an attempt to autolysis with valproic acid, benzodiazepines and neuroleptic. The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication. She presents an acute encephalopathy with prolonged status epilepticus, a lactic metabolic acidosis and hematologic disorders such as bicytopenia. Treatment including L-carnintine and continuous veno-venous haemodialysis (CVVHD) was rapidly introduced to prevent the occurrence of cerebral oedema. The evolution was favourable despite the occurrence of a nosocomial ventilation acute lung injury. The patient had motor sequelae of cranial nerves following status epilepticus extended, which disappeared spontaneously after several days.

Language: fr

Keywords

Humans; Female; Young Adult; Respiration, Artificial; Suicide, Attempted; Electroencephalography; Anticonvulsants; Hemofiltration; Carnitine; Thrombocytopenia; Acidosis, Lactic; Valproic Acid; Status Epilepticus; Acute Lung Injury; Cranial Nerve Diseases