Citation

Atkinson JH, Jin H, Shi C, Yu X, Duarte NA, Casey CY, Franklin DR, Vigil O, Cysique L, Wolfson T, Riggs PK, Gupta S, Letendre S, Marcotte TD, Grant I, Wu Z, Heaton RK, HIV Neurobehavioral Research Center Group. J. Affect. Disord. 2011; 130(3): 421-428.

Copyright

(Copyright © 2011, Elsevier Publishing)

DOI

10.1016/j.jad.2010.10.039

PMID

21094530

PMCID

PMC3307799

Abstract

BACKGROUND: China's HIV epidemic commenced in its agrarian provinces through contaminated commercial plasma donation centers and is now becoming a public health concern nationwide. Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, employment, and life quality.
METHODS: HIV-infected (HIV+) former plasma donors (N=203) and HIV-negative (HIV-) donor controls (N=198) completed the World Mental Health Survey Composite International Diagnostic Interview to determine lifetime major depressive disorder (MDD), substance use disorders, and suicidality. Current mood and suicidality were assessed with the Beck Depression Inventory-II. Everyday function was measured by an Activity of Daily Living questionnaire; life quality was evaluated by the Medical Outcomes Study-HIV.
RESULTS: HIV+ participants had known their infected status for 2 years on average. Most were taking antiretroviral treatment and had frank AIDS. Rates of current MDD were similar across groups (1-2%), but HIV+ had a higher frequency of lifetime MDD (14% vs. 5%, p<.05). Its onset preceded date of known infection in one-third of cases. Alcoholism was the only substance use disorder detected; HIV+ had a higher proportion of lifetime substance use diagnoses (14% vs. 6%, p<.05). Depression and AIDS independently predicted worse daily functioning and life quality, and unemployment.
LIMITATIONS: The epicenter of China HIV has moved into urban injection drug users, limiting the representativeness of this sample.
CONCLUSIONS: High rates of MDD and its impact suggest that in China, as elsewhere, comprehensive care requires detection and treatment of mood disorder.

Language: en

Keywords

Humans; Risk Factors; Adult; Female; Male; Middle Aged; Adolescent; Suicide; Young Adult; Psychiatric Status Rating Scales; Substance-Related Disorders; Rural Population; Surveys and Questionnaires; China; Case-Control Studies; HIV Infections; Depressive Disorder, Major; Blood Donors