Citation

Chevalier N, Hieronimus S, Vandenbos F, Delmont E, Cua E, Cherick F, Paquis P, Michiels JF, Fenichel P, Brucker-Davis F. Annales D'endocrinologie 2010; 71(6): 548-552.

Copyright

(Copyright © 2010)

DOI

10.1016/j.ando.2010.08.003

PMID

20850107

Abstract

Cushing's disease is usually associated with higher mortality rate, especially from cardiovascular causes. Development or exacerbation of autoimmune or inflammatory diseases is known to occur in patients with hypercortisolism after cure. We report for the first time a 34-year old woman with a psychiatric background, who developed four months after the surgical cure of Cushing's disease an acute disseminated encephalomyelitis (ADEM) presenting initially as a psychiatric illness. We hypothesize that the recent correction of hypercortisolism triggered ADEM and that the atypical presentation, responsible for diagnosis delay, led to the death of this patient.

Language: en

Keywords

Humans; Adult; Female; Fatal Outcome; Magnetic Resonance Imaging; Suicide, Attempted; Obesity; Brain; Psychotic Disorders; Immunohistochemistry; Demyelinating Diseases; Blood Glucose; Hydrocortisone; Adrenocorticotropic Hormone; Pituitary ACTH Hypersecretion; Encephalomyelitis