Citation

Peces R, Azorín S, Peces C, Selgas R. Nefrologia 2010; 30(1): 127-130.

Copyright

(Copyright © 2010, Sociedad Espanola de Nefrologia)

DOI

10.3265/Nefrologia.pre2010.Jan.10217

PMID

20098475

Abstract

Carbamazepine is used in the treatment of epilepsy, and also prescribed in neuralgic pain syndromes, and certain affective disorders. Carbamazepine intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, arrhythmia, hemodynamic instability and death. The drug's relatively high molecular weight, elevated volume of distribution and intense protein-binding render it difficult to extracorporeal removal, but published experience with hemoperfusion or hemodialysis present variable results. We describe a case report involving carbamazepine intoxication who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of carbamazepine was reduced with rapid lowering of carbamazepine levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, extended charcoal hemoperfusion should be considered for serious carbamazepine intoxication because free as well as bound drug fractions are eliminated via this technique.

Language: es

Keywords

Humans; Adult; Female; Poisoning; Suicide, Attempted; Carbamazepine; Acute Disease; Hemoperfusion