Citation

Busch SH, Frank RG, Martin A, Barry CL. Med. Care Res. Rev. 2011; 68(1): 96-111.

Copyright

(Copyright © 2011, SAGE Publishing)

DOI

10.1177/1077558710374197

PMID

20675349

PMCID

PMC2974787

Abstract

Steep declines in pediatric antidepressant use were documented following the 2004 release of new safety information associating antidepressants with a risk of suicidality. The authors examine whether declines in pediatric antidepressant use were steeper among individuals with certain clinical or family characteristics. The authors find that declines in antidepressant use were associated with new (as compared with ongoing) treatment episodes. Although rates of antidepressant use were higher among children of college-educated parents prior to risk disclosures, these children were more likely to forgo antidepressant medication than children of less educated parents after risk disclosures. The authors find that both children with and without psychiatric impairment experienced declines in antidepressant medication use following the risk warnings, although the decline occurred more quickly in the latter group. The authors' findings highlight the need for additional data to assess the effects of risk disclosures on treatment patterns and health outcomes.

Language: en

Keywords

Humans; Risk Factors; United States; Child; Adolescent; Depression; Suicide; Suicide, Attempted; United States Food and Drug Administration; Antidepressive Agents; Disclosure; Drug Labeling; Practice Patterns, Physicians'; Drug Industry